Damien,
I always dial in -1.0 to -1.5 EV for wide lens shooting. Shooting a mid-range zoom, maybe -1.0. For macro (which is a very rare occurence for me, not being a macro shooter these days) I might dial in -.5 EV if any.
I still shoot in manual mode for wide and mid-range zoom shooting, setting a shutter speed for background water color based on my experience and depth of water. Then I only have one parameter to adjust, f-stop. Reading a light meter in the viewfinder? Not me....I may glance at how far my manually chosen shutter speed and f-stop settings are, like minus 2/3 - 1.5 stops, knowing my strobe light will lighten my foreground subject. But actually metering the background light....Again, not these days.
You must still try and fill 1/2 - 2/3 of the frame with a main colorful subject for your strobe light to reflect off and get back to the camera. But eTTL2 works remarkably well if you practice, eliminating guessing at subject distances, adjusting strobe output manually, etc.
Good luck!
dhaas