I use TTL for wide-angle much of the time, and almost always for macro.
The biggest advantage of TTL for wide-angle, IMHO, is the ability to control both strobes output while bracketing by adjusting the flash compensation control on the housing. Bracketing effective strobe power while shooting manual strobe requires adjusting the power settings on each strobe. Assuming both strobes are mounted on long strobe arms on each side of the housing (as they should be for w/a), this is rarely really feasible when shooting animals or fish, though it can be done for static reef scenics.
Using TTL requires a relatively close subject that occupies a substantial portion of the frame, but this limitation also applies to shooting TTL with a film SLR.
I've found that w/a TTL on the S2 needs -0.5 to -1.0 flash exposure compensation; I use one of those settings as a starting point for bracketing the flash exposure.
This Barramundi cod (Cromileptes altivelis), shot with the 17-35 mm zoom, is an example of an ideal subject for w/a TTL.

In contrast, this shot of two Moorish idols (Zanclus cornutus) needed manual strobe control - the main subjects don't fill enough of the frame to generate a good return to the TTL sensor, and there isn't anything else big enough or close enough in the background to help. Using TTL here would have probably blown out the light-colored areas on the Moorish idols.

Here's some more shots, including both macro and w/a, using the Fuji S2, most (but not all) of which were shot using TTL.
Komodo - Fuji S2
Robert Delfs