I've been leaning toward shooting with one strobe ever since I attended the Digital Shootout in June. The instructors there were basically interested in shadows more than even lighting, and you can get some pretty dramatic effects with one strobe.
And if you are shooting with a snoot, even more so.
My suggestions are as follows:
-take off any diffusers. Using only one strobe causes hard shadows. Lean into that.
-in general a strobe should be somewhere above the subject because lighting looks unnatural from other positions
-no, you do not need to mount your strobe directly in front of the lens. Put it there if the resulting shadows will look best from that position. Move it left or right as the scene indicates.
-whether dual strobes or not, consider the reflectivity of the surroundings. If you are shooting an object sitting in sand, move your strobe(s) very high up as the white sand will reflect a lot of light.
Shooting with a snoot can give very dramatic lighting, but it can be a royal pain to line up on a target. As least for now (I'm a snoot beginner), I find I need to position the snoot/strobe right in front of the lens and directly above it to have any hope of getting lined up on a target. But you can get shots like these:


