I have been using this lens for some time now, and have not yet tried it with any kind of magnifier/close up lens so far.
I found it to be very easy to use, fast AF (with my simple setup that includes only one strobe at the moment). Still learning though. Never had the need with MF so far, but then again, you can always do that without the zoom gear but by moving the camera.
I keep it at 0.19 - infinity AF setting, F8, 1/250 (as that is max sync speed on EM5), below are some results from todays dive.