Just to deploy a little science here...
Figures are all Sea&Sea/Nikon quoted ones.
Housings
Z6/7: 239 x 169 x 158 (2,700g)
D850: 246 x 202 x 140 (2,850g)
So the MDX D850 is 7 mm higher, and 33mm deeper, but is actually 18 mm thinner than the MDX Z6. (I suspect this is to accommodate the FTZ adaptor.
Weight difference is 150g (less than the weight of an iPhone 11!)
As a comparison, Ikelite LX100 : 152 x 185 x 150 mm (1,600g)
Lenses:
16-35mm f/4 for D850: 680g
14-30mm f/4 for Z6/7: 485g
So Z6/7 lens is 195g lighter
Ports:
With the above lenses, they both use the same domes so weight/size is the same.
Z6/7 uses a 40mm extension at 234g
D850 uses 2 x 40mm extensions 468g
So for rectilinear wide angle, the weight saving is around 579g. Space saving is negligible. Just under 600g may be significant, but I don't see it as being a worthwhile reason to spend $1000s in order to do so!
For this type of shooting, when apertures need to be f/13 or greater to get details in the corners, both systems require big strobes!
WWL is not rectilinear, and has quite a lot of barrel distortion. It would be wrong to compare the optical results of using WWL with those of a large dome and (in the case of a Nikon DX camera) a 10-24mm f/3.5-4.5 for example. Both are great, but do not replace each other optically.
Adam