My thoughts on this may differ from the norm. I've been shooting FX since the D700 came out, currently using a D850 in a Nauticam housing. I have only two lens choices: 105vr and 16-35. I've tried adding some flexibility with the 60mm macro and a 1.4tc on the 105, but the 60mm focal length is too short, and the 1.4tc robbed too much sharpness for my liking.
When I look at an APSC, I see a tradeoff. That tradeoff is image quality versus lens choices. Yes, I know that for most of you, the sheet size of the FX rig versus an APSC rig is a big deal, and it is. But for me, image quality is bigger. What I see as a clear win for APSC is having more useful lens choices, specifically a normal midrange zoom option. Fisheye? I can get the 8-15mm Nikkor, or others.
And while I'm sitting here thinking, I suddenly start thinking about cropping, how much I do it, and the fact that a DX camera simply 'precrops' the image, I'm wondering why one couldn't simply stick the same DX lenses and smaller ports on the D850 and shoot it in DX mode? 19mp DX crop is quite good, and I often crop to DX and well beyond in post processing.
So - not an ideal choice, but it IS still a choice.